Sunday, May 29, 2011

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Cancer Cells Accelerate Aging And Inflammation In The Body To Drive Tumor Growth

Researchers at the Kimmel Cancer Center at Jefferson have shed new light on the longstanding conundrum about what makes a tumor grow and how to make it stop. Interestingly, cancer cells accelerate the aging of nearby connective tissue cells to cause inflammation, which ultimately provides "fuel" for the tumor to grow and even metastasize.

This revealing symbiotic process, which is similar to how muscle and brain cells communicate with the body, could prove useful for developing new drugs to prevent and treat cancers. In this simple model, our bodies provide nourishment for the cancer cells, via chronic inflammation.

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Combination Niacin Does Not Improve Heart Attack And Stroke Risk

Niacin, also known as vitamin B3, when combined with statin only therapy for patients with heart and vascular disease does not lower heart attack and stroke risk - a finding which made the National Heart, Lung, and Blood Institute and Abbott Laboratories end a clinical trial 18 months early.

The trial, called AIM-HIGH, was aimed to see whether individuals with heart and vascular disease might have better outcomes if they added niacin to their statin treatment.
Tuesday, May 24, 2011

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Smoking during pregnancy increases children's heart disease risk factors

University of Sydney researchers have discovered that children whose mothers smoke during pregnancy had lower levels of the type of cholesterol known to protect against heart disease in later life - high-density lipoprotein (HDL) cholesterol.
By the age of eight children born to mothers who smoked while they were pregnant had HDL cholesterol levels of about 1.3 millimoles per litre (mmol/L) compared to the more normal level of 1.5 mmol/L in children whose mothers had not smoked.
This effect was independent of whether children were exposed to cigarette smoke after birth, suggesting prenatal exposure had the most impact on subsequent development. The research, published online in the European Heart Journal, was led by David Celermajer, Scandrett Professor of Cardiology at the University of Sydney.